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The robustness of a 6495D LC/TQ was tested using undiluted salmon extract. During the experiment, the system was exposed to more than 130 mL of the matrix over a period of ~3 weeks of continuous operation, without any maintenance.
This poster is a demonstration of Pro iQ Plus robustness & ruggedness against these factors over a series of 800 consecutive injections of analytes spiked in crashed plasma matrix.
Acylcarnitine profile analysis is a commonly requested analysis in genetic disease research laboratories due to their wide metabolic involvement. A new comprehensive LC-MS/MS method was developed to quantify 32 acylcarnitine species.
We employed an Agilent 6546 LC/Q-TOF in conjunction with the Agilent PCDL TCM MS/MS Database, Sirius, and Global Natural Product Social Molecular Networking (GNPS) to analyze an unknown Chinese patent medicine.
This poster demonstrates a 2D-LC/Q-TOF approach to identify the free drug content of an ADC sample. The method combines size exclusion chromatography (SEC) in the first dimension (1D) and reversed-phase (RP) separation in the second dimension (2D).
A reducing online 2D-LC/TOF MS method was developed to measure antibody heavy chain glycoforms directly from a bioreactor. The measurement was used in a PID control loop to control the glycoforms during a 30 day bioreactor run.
Establish correlations between abundance settling time and changes in multiple acquisition parameters from empirical data. Apply the correlations to ensure instrument performance at a high sampling rate with minimal inter-measurement delays.
In-source chemical charge reduction allows precise control over protein charge distributions. This work explores the influence of charge reduction on protein structure and top-down fragmentation.
In this study we demonstrate in-depth LC-MS/MS sequence and modification characterization of multiple GLP-1 receptor agonists by implementing electron capture dissociation and ExDViewer for fragment analysis.
A robust microflow method for oligonucleotide analysis which dramatically reduces the consumption of HFIP and TEA. Carried out using the Axcend Focus LC ? coupled with the Agilent LC/MSD Pro iQ Plus.