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本文介紹了在生物樣品中 OGN 藥物 LC/MS 方法開(kāi)發(fā)常見(jiàn)的問(wèn)題及優(yōu)化方案。使用定制合成的無(wú)生物活性的 siRNA 序列作為對(duì)照品,模擬血漿作為空白基質(zhì),參照中國(guó)藥典《9012 生物樣品定量分析方法驗(yàn)證指導(dǎo)原則》進(jìn)行部分方法學(xué)確認(rèn)。使用 SPE 前處理技術(shù),結(jié)合 Agilent 6495D UH...
- 文件出版號(hào): 5994-8142ZHCN
- 創(chuàng)建日期: 19 三月 2025
- 2 MB
使用 Agilent Cary 3500 多池控溫紫外-可見(jiàn)分光光度計(jì)同步進(jìn)行多個(gè)實(shí)驗(yàn),在不同條件下評(píng)估 RNA 純度。
- 文件出版號(hào): 5994-7892ZHCN
- 創(chuàng)建日期: 14 十一月 2024
- 966 KB
PLRP-S reversed-phase HPLC columns deliver the pure oligonucleotides required for genomic applications.
- 文件出版號(hào): 5990-8187EN
- 創(chuàng)建日期: 10 三月 2025
- 371 KB
Packaging insert for Agilent A-Line Supplies Quick Connect fittings, contains installation instructions and ordering information.
- 文件出版號(hào): 01200-90114
- 創(chuàng)建日期: 31 一月 2025
- 243 KB
Direct 2D-LC analysis of oligonucleotides in solution with high salt content, with online desalting in the first dimension and IP-RPLC in the second dimension.
- 文件出版號(hào): 5991-9490EN
- 創(chuàng)建日期: 14 十月 2024
- 912 KB