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Charge variant analysis of monoclonal antibodies with pH gradients using the Agilent 1260 Infinity Bio-inert Quaternary LC with alternating column regeneration.
The evaluation of different salt gradients was performed on the Agilent 1290 Infinity II Bio LC System and analyzed for resolution as well as reproducibility.
Method ransfer from a 1260 Infinity Bio-inert LC to a 1260 Infinity II Bio-inert LC showing proof of equivalency for charge variant analysis of rituximab
Small –scale purification of a monoclonal antibody from a cell lysate and the subsequent analysis on a single instrument, the Agilent 1260 Infinity Bio-inert Quaternary LC.
The Agilent 1260 Infinity Bio-inert Quaternary LC with fluorescence detection and Agilent Bio SAX analyzed N-linked glycans with.excellent resolution and precision.
This Technical Overview describes a LC system with 3 detectors in a multi-user environment operated with Agilent MassHunter Walkup Software for LC/MS and LC systems.